Herceptin (trastuzumab)

Information on this site is not intended as medical advice and should not be used as a substitute for consulting with qualified doctor.

Trastuzumab is a recombinant humanised monoclonal antibody that selectively targets the extracellular domain of the Human Epidermal growth factor Receptor 2 protein (HER2). HER2 protein exists on normal cells and HER2+ tumor cells. It is believed to block downstream signaling pathways. Herceptin flags the tumor cell for destruction by the body's immune system, known as antibody dependent cellular cytotoxicity (ADCC).1

Herceptin prevents HER2 shedding.2


In Bangladesh Herceptin is approved for the following indications.3

Herceptin IV and Herceptin SC:

Breast Cancer

Metastatic Breast Cancer (MBC)

Herceptin is indicated for the treatment of patients with metastatic breast cancer who have tumors that overexpress HER2:

a) as monotherapy for the treatment of those patients who have received one or more chemotherapy regimens for their metastatic disease.

b) in combination with paclitaxel or docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease.

c) in combination with an aromatase inhibitor for the treatment of patients with hormonereceptor-positive metastatic breast cancer .


Early Breast Cancer (EBC)

Herceptin is indicated for the treatment of patients with HER2-positive early breast cancer:

  • following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable).
  • following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel.
  • in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin.
  • in combination with neoadjuvant chemotherapy followed by adjuvant Herceptin, for locally advanced (including inflammatory) breast cancer or tumours > 2 cm in diameter.


Herceptin IV only:

Advanced Gastric Cancer

Herceptin in combination with capecitabine or intravenous 5-fluorouracil and a platinum agent is indicated for the treatment of patients with HER2-positive advanced adenocarcinoma of the stomach or gastro-esophageal junction who have not received prior anticancer treatment for their metastatic disease.


For more disease and medicine related queries you may discuss with your physician.


In Bangladesh Herceptin is available as

Vials 440 mg (IV)

Vial 600 mg/5ml (SC)

Winning the battle against breast cancer

Breast cancer is the leading cancer among all cancer types in women worldwide including Bangladesh. About 1 out of every 4 cancer patients in the world suffers from this cancer. However, the good news is, if the disease can be diagnosed at an early stage and proper treatment can be given it can be cured in 99% cases, which comes down to 27% for Advance Stage. Although most of the cancers are difficult to diagnose at an early stage, breast cancer is often more likely to be diagnosed early. All you need is the right information and awareness. You can diagnose the disease at an early stage through regular breast examinations (BSE).


1. Proposed Mechanism of Action, Herceptin MOA. [Internet; cited 2018, November 08]. Retrieved from https://www.herceptin.com/hcp/treatment/moa

2. Molina MA, Codony-Servat J, Albanell J, Rojo F, Arribas J, Baselga J. (2001). Trastuzumab (Herceptin), a humanized anti-HER2 receptor monoclonal antibody, inhibits basal and activated HER2 ectodomain cleavage in breast cancer cells. PubMed, Cancer Res. 61(12):4744-9. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/11406546#

3. Herceptin Product Information _ FE-English Ro 45-2317 _ November 2018