Tecentriq (atezolizumab)

Information on this site is not intended as medical advice and should not be used as a substitute for consulting with qualified doctor.

Tecentriq is a monoclonal antibody designed to bind with a protein called PD-L1 (programmed death-ligand 1) expressed on tumour cells and tumour-infiltrating immune cells, blocking its interactions with both PD-1 and B7.1 receptors.1

PD-L1 acts to switch off immune cells that would otherwise attack the cancer cells. By attaching to PD-L1 and reducing its effects, Tecentriq increases the ability of the immune system to attack the cancer cells and thereby slow down progression of the disease.2


In Bangladesh Tecentriq is approved for the following indications.3

Urothelial carcinoma

Tecentriq as monotherapy is indicated for the treatment of patients with locally advanced or metastatic urothelial carcinoma (UC):

  • after prior chemotherapy, or
  • who are considered cisplatin ineligible and whose tumours have a PD-L1 expression ≥ 5%, or
  • who are not eligible for any platinum-containing chemotherapy regardless of level of tumor PD-L1 expression.

 

Non-small cell lung cancer

Tecentriq, in combination with bevacizumab, paclitaxel and carboplatin, is indicated for the first-line treatment of patients with metastatic non-squamous non-small cell lung cancer (NSCLC). Patients with EGFR or ALK genomic tumor aberrations should have received targeted therapy if clinically indicated prior to receiving Tecentriq. [33]

Tecentriq, in combination with nab-paclitaxel and carboplatin, is indicated for first-line treatment of patients with metastatic non-squamous NSCLC who do not have EGFR or ALK genomic tumor aberrations.

Tecentriq as monotherapy is indicated for the first-line treatment of patients with metastatic NSCLC whose tumors have a PD-L1 expression ≥ 50% tumor cells (TC) or ≥ 10% tumor-infiltrating immune cells (IC) and who do not have EGFR or ALK genomic tumor aberrations.

Tecentriq as monotherapy is indicated for the treatment of patients with locally advanced or metastatic NSCLC after prior chemotherapy.

 

Small cell lung cancer

Tecentriq, in combination with carboplatin and etoposide, is indicated for the first-line treatment of patients with extensive-stage small cell lung cancer (ES-SCLC).

 

Triple-negative breast cancer

Tecentriq, in combination with nab-paclitaxel, is indicated for the treatment of patients with unresectable locally advanced or metastatic triple-negative breast cancer (TNBC) whose tumors have PD-L1 expression ≥1%, and who have not received prior chemotherapy for metastatic disease.

 

Hepatocellular carcinoma

Tecentriq, in combination with bevacizumab, is indicated for the treatment of patients with unresectable hepatocellular carcinoma (HCC) who have not received prior systemic therapy.

 

For more disease and medicine related queries you may discuss with your physician.

 

In Bangladesh Tecentriq is available as

Single-use vial of 60 mg/ml (20 mL vial containing a total of 1,200 mg atezolizumab)

 

References

1. Roche - Tecentriq (atezolizumab) [Internet; cited 2020, March 17]. Retrieved from https://www.roche.com/products/product-details.htm?productId=8c738504-101a-40b9-867b-d907c578df51

2. Tecentriq | European Medicines Agency [Internet; cited 2020, March 17]. Retrieved from https://www.ema.europa.eu/en/medicines/human/EPAR/tecentriq

3. Tecentriq Product Information _ BD RO 554-1267 _ January 2020